Rodent Surgical Monitor+

The Indus Rodent Surgical Monitor⁺ is an advanced, integrated surgical warming and monitoring solution for preclinical research in mice, rats and other small animals.

The system consists of three components:
Touchscreen Display Unit, Heated Surgical Platform and Temperature Probe.

Optional components:
Pulse Oximetry Thigh Clip, Pressure Adapter Cable and Catheters, External Needle Electrodes

Brochure

Spec Sheet

References

Temperature

Core body temperature is measured by rectal probe and regulated via the Heated Surgical Platform.

Pressure

Measure high fidelity arterial and ventricle pressure in mice and rats using a solid state pressure catheter.

ECG

High-resolution multi-lead ECG measured by noninvasive paw or subcutaneous needle electrodes.

SpO2

Measure arterial blood oxygenation non-invasively in mice and rats using a thigh clip sensor.

Heart Rate

Heart rates between 60 – 999 bpm are automatically calculated from the R peaks of the ECG signal.

Respiration

Properly titrate anesthesia based on respiration rate, measured using electrical impedance.

Touchscreen Display Unit

Configurable, clear waveforms and numeric panels provide information to monitor subject physiological status. Recording, playback and export functions are included to make data collection easy.

Type	High Resolution Color with Capacitive Touch
Size & Resolution	10.1 Inches; 2560 x 1600 pixels

Storage Capacity	Up to 32 GB Total (~25.5 GB for Data Storage)
Power Supply	Universal Adapter (110 – 240 VAC)
Connection to Heated Surgical Platform	Wireless or optional USB-C

Physiologic Measurements

Measurement	Range
Heart Rate (Lead I, II, II)	200-999 BPM
Respiration Rate	15-400 BrPM
Core Temperature	0 – 50.0°C
Pad Temperature	25.0 – 43.5°C
R-R Interval (Lead I, II, III)	60 – 1000 ms
SpO2 *	80 – 100%
Pressure **	-50 – 300 mmHg

Waveform Display Options
ECG Lead I, II, III
ECG Lead aVL, aVR, aVF
Respiration
Respiration (from ECG)
Pulse Plethysmogram *
Pressure **

* SpO2 and Pulse Plethysmogram measurements require the “Pulse Oximeter software upgrade & clip”

** Pressure measurements require the “Pressure software upgrade and pressure catheters”

Features that help you do better science…

Real Time Monitoring
clearly labelled numeric panels and measurement waveforms make it easy to monitor critical parameters

Easy Documentation
a single image can capture animal ID, vital signs, study ID, researcher, date, time and all filter settings

Customizable Presets
define optimal study conditions and ensure consistency between subjects and collaborating labs

Standalone Data Collection
capture data, make comments and view recordings on the tablet to quickly take measurements and verify experiment details

Heated Surgical Platform

The surgical-grade stainless steel operating platform is easy to clean and disinfect, designed to support surgical best practices. It incorporates intelligent zone heating, ultra-low noise, high-resolution ECG electronics, noninvasive electrodes and a port for external needle electrodes for when subjects cannot be laid prone or supine.

Dimensions	7.6 x 11.6 x 0.75 inches
Weight	3.4 pounds
Heater Type	Responsive with Multiple Zone Control
Heater Uniformity	< 0.5°C Across Active Area
Startup Time	< 2 minutes from room temperature
Heater Set Temperature	Adjustable, 25.0 – 43.5°C by 0.1°C
Power Supply	Universal Adapter (100-240 VAC)
Noninvasive Electrodes	Two sets of limb ECG contact electrodes; inner set for mouse, outer for rats or subjects of similar size
External Electrodes	Standard 1.5mm DIN ECG Leads (ANSI/AAMI EC53 & DIN 42-802 compliant)

Temperature Probe

Each Rodent Surgical Monitor⁺ is delivered with a single rectal temperature probe. Customers may select between probes ideal for adult mice or for adult rats.

The temperature probe sensor is a Copper-Constantan Thermocouple, located at the tip of the probe. Probe temperature resolution is +/-0.1°C. Calibrated probe accuracy is +/-0.1°C at operating temperature.

Versatile

three sets of electrodes make it easy to work with small mice, large rats and many small animals in between

Dynamic

responsive electronic heating can respond to changing lab conditions within seconds, not minutes

Flexible

expansion modules allow you to easily add functionality later as your lab and study’s needs change

Optional Upgrades

4 or 8 Channel Analog Output Cable

The 4 or 8 Channel Analog Output Cable allows the researcher to export raw data measurements from the Rodent Surgical Monitor⁺ to virtually any data acquisition system. A total of four or eight output channels are included, each configurable for optimal data output control. In addition, the cable can be used as an R-trigger for ultrasound imaging systems, as a TTL trigger for high-speed dual camera image capture systems and to supply data to many different brands of data acquisition systems. Each channel can be individually exported with it’s own filtering options.

Analog Output Specifications
BNC Outputs	4 or 8 Channels
Sample Rate	4 kHz
DAC Resolution	14-bit
Output Impedance	75 ohms typical
Output Voltage	± 5V
Maximum Output Current	30mA short circuit current
Slew Rates	1.8V per microsecond
Settling Time	5µs typical
Linearity Error	± 1 LSB
High Pass Fitlering	Off, 0.2Hz, 0.5Hz, 1Hz, 2Hz, 5Hz, or 10Hz
Low Pass Filtering	Off, 1Hz, 2Hz, 5Hz, 10Hz, 20Hz, 30Hz, 100Hz, 200Hz, 500Hz, or 1000Hz
Notch Filtering	This filter suppresses cyclic 50Hz or 60Hz AC power line noise that can interfere with the instrumentation

Available Signal Outputs
ECG Lead I, II, III	ECG Lead II Trigger
Respiration Waveform	Core Temperature
Pad Temperature	Pulse Plethysmograph (IR)
Pulse Plethysmograph (R)	Pressure

Pulse Oximetery Option

The Pulse Oximeter Option allows you to noninvasively measure arterial blood oxygenation. This adds another real-time continuous data stream to the Rodent Surgical Monitor⁺, providing valuable information about depth of anesthesia and ventilation efficacy. Pulse oximetry has been mandated in hospital care for more than a decade: the preclinical research community has taken note of this and current NIH guidelines repeatedly suggest monitoring pulse oximetry during surgery and postoperative care to ensure correct anesthesia delivery and ventilation.

Cable Specifications
Pulse Rate Range	200-999 BPM
Pulse Rate Resolution	1 BPM
Sp02 Range	80% – 100%
Sp02 Resolution	1%
Connector	Built-in Connector
Available Sensors	Thigh Clip (Mouse & Rat)

Pressure Catheter Option

The Pressure Catheter Option includes a software and firmware update, along with a catheter connection cable. When connected to an Indus pressure catheter, measurement of arterial, venous, or ventricular pressures can be performed. This adds another real time continuous data stream to the Rodent Surgical Monitor⁺

The Indus high fidelity rodent pressure catheters are specifically designed for use with mice and rats. These catheters have solid state sensors mounted at the tip that measure pressures with a high degree of precision. They are ideal for arterial, venous, or ventricular pressures due to the solid state sensor’s ability to accurately respond to minute and rapid changes in pressure.

Pressure Catheter Specifications
Available Sizes	1.2F and 1.6F
Sensor Type	Solid state sensor, mounted at the tip of the catheter; pressure membrane recessed for protection
Catheter Material	Polymide tubing, providing balance of flexibility and rigidity
Pressure Resolution	10uV/mmHg; higher than the industry standard

Pressure Amplifier Specifications
Input Pressure Range	-50 – 300 mm Hg
High Pass Filter Settings	None
Low Pass Filter Settings	Off, 30Hz, 100Hz, 200Hz, 500Hz, or 1000Hz
Notch Filter Settings	Off, 50Hz, or 60Hz
Calibration	Allows zero calibration and a high-point calibration
Pressure Catheter types	Works with most commercially available catheters for small animals or in-house built fluid filled catheters

NRC Guide for the Care and use of Laboratory Animals

The Indus Rodent Surgical Monitor⁺ ensures scientist meet today’s laboratory standards as detailed by the NRC. The following are excerpts from the guide… to download a full copy click here.

“Careful monitoring and timely attention to problems increase the likelihood of a successful surgical outcome. Monitoring includes routine evaluation of anesthetic depth and physiologic functions and conditions, such as body temperature, cardiac and respiratory rates and pattern, and blood pressure, and should be appropriately documented… Maintenance of normal body temperature minimizes cardiovascular and respiratory disturbances caused by anesthetic agents, and is of particular importance in small animals where the high ratio of surface area to body weight may easily lead to hypothermia.” [pg. 119]

“For anesthesia delivery, precision vaporizers and monitoring equipment (e.g., pulse oximeter for determining arterial blood oxygen saturation levels) increase the safety and choices of anesthetic agents for use in rodents and other small species.” [pg. 122]